SAMAIR serves at least seven different mission organizations as well as national missionaries, allowing an assortment of ministries to take place that would otherwise be impossible. 

Students are brought to Pucallpa to receive extensive Bible and leadership training.

Missionaries are transported and supported in order to reach the unreached, plant churches, and train church leaders.

National missionaries are flown to remote areas to minister to their own countrymen.

Emergency Medical Flights are carried out on a continual basis as requested by misions, communities, and local government agencies.